规格：50 µL/100 µL
货号：PN0153
价格：1350元/50 µL、2200元/100 µL
抗体来源 | Rabbit |
克隆类型 | Monoclonal |
交叉反应 | Human |
产品应用 | WB: 1:1000-1:2000 ICC/IF: 1:50-1:200 FC: 1:20-1:100 |
理论分子量 | 22kDa |
细胞定位 | Cytoplasm,Inflammasome, Endoplasmic reticµLum, Mitochondrion, Nucleus |
性 状 | Liquid |
浓 度 | |
免 疫 原 | A synthesized peptide derived from human ASC |
亚 型 | IgG |
纯化方法 | Affinity-chromatography |
Uniprot ID | |
缓 冲 液 | pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
保存条件 | Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
Functions as a key mediator in apoptosis and inflammation.Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner.Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8-dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase-9, -2 and -3.
