规格：50µL/100µL
货号：PN0203
价格：1350元/50µL；2200元/100 µL
全称 | nitric oxide synthase 2, inducible |
别名 | NOS2, EC:1.14.13.39, Hepatocyte NOS, HEP-NOS, Inducible NO synthase |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Pig, Chicken, Bovine |
产品应用 | WB : 1:500-1:4000 IF/ICC : 1:50-1:500 FC (INTRA) : 0.40 ug per 10^6 cells in a 100 µl suspensi |
理论分子量 | 131kDa |
细胞定位 | 细胞质 |
性 状 | Liquid |
浓 度 | 900 ug/ml |
免 疫 原 | Peptide |
亚 型 | IgG |
纯化方法 | Antigen affinity purification |
Uniprot ID | |
缓 冲 液 | pH: 7.2，Preservative: 0.01% Sodium azide，Constituents: PBS, 40% Glycerol, 0.05% BSA |
保存条件 | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
NOS2, also named as iNOS and NOS2A, produces nitric oxide (NO) which is a messenger molecµLe with diverse functions throughout the body. NO is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission, antimicrobial and antitumoral activities. NOS2 is a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. iNOS has a very short half-life due to rapid degradation by calpain. iNOS monomer is a direct substrate of calpain I and can be cleaved by calpain I at the canonical CaM-binding site(503-532aa) of iNOS, and then a ~70 kDa band can be detected by western (PMID:11786228). This antibody is specific to NOS2.
