规格：50µL/100µL
货号：PN0181
价格：1350元/50µL；2200元/100 µL
全称 | protein tyrosine phosphatase, receptor type, C |
别名 | B220, EC:3.1.3.48, GP180, L CA, LCA |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Pig, Canine, Bovine, Sheep |
产品应用 | WB : 1:5000-1:50000 IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate IHC : 1:1000-1:6000 IF-P : 1:50-1:500 IF-FRO : 1:200-1:800 IF/ICC : 1:50-1:500 |
理论分子量 | 1304 aa, 147 kDa |
细胞定位 | 细胞膜 |
性 状 | Liquid |
浓 度 | 700 ug/ml |
免 疫 原 | CD45 fusion protein Ag13712 |
亚 型 | IgG |
纯化方法 | Antigen affinity purification |
Uniprot ID | |
缓 冲 液 | pH: 7.2，Preservative: 0.01% Sodium azide，Constituents: PBS, 40% Glycerol, 0.05% BSA |
保存条件 | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
Protein tyrosine phosphatase receptor type C (PTPRC) is also known as CD45 antigen, which was originally called leukocyte common antigen (LCA). CD45 is an enzyme required for T-cell activation through the antigen receptor consisting of two intracellµLar phosphatase domains, a transmembrane domain and an extracellµLar domain. Upon T-cell activation, CD45 recruits and dephosphorylates SKAP1 via an interaction through the first PTPase domain, which is the only domain to possess intrinsic kinase activity. However, both domains are required for appropriate phosphatase and T-cell antigen receptor activity
