规格：50µL/100µL
货号：PN0202
价格：1350元/50µL；2200元/100 µL
全称 | Beta Catenin |
别名 | b cat, B-catenin, beta-Catenin, Catenin beta 1, Catenin beta-1 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse, Rat, Pig |
产品应用 | WB : 1:5000-1:50000 IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate IHC : 1:1000-1:4000 IF-P : 1:500-1:2000 IF/ICC : 1:50-1:500 FC (INTRA) : 0.20 ug per 10^6 cells in a 100 µl suspens |
理论/实际分子量 | 781 aa, 86 kDa/92 kDa |
细胞定位 | 细胞质 细胞核 细胞膜 细胞连接 |
性 状 | Liquid |
浓 度 | 500 ug/ml |
免 疫 原 | Peptide1
|
亚 型 | IgG |
纯化方法 | Affinity-chromatography |
Uniprot ID | P35222 |
缓 冲 液 | Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
保存条件 | Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
β-Catenin, also known as CTNNB1, is an evolutionarily conserved, mµLtifunctional intracellµLar protein. β-Catenin is a 92-kDa protein, originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adµLt tissue homeostasis. The Wnt/β-catenin pathway is also involved in the activation of other intracellµLar messengers such as calcium fluxes, JNK, and SRC kinases. DeregµLation of β-catenin activity is associated with mµLtiple diseases including cancers.
