规格：50µL/100µL
货号：PN0117
价格：1350元/50µL，2200元/100 µL
全称 | IL-2 Receptor alpha rabbit polyclonal antibody |
别名 | IL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
|
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | mouse，Rat |
产品应用 | WB=1:500-1000, IHC/IF=1:200-1000, |
理论分子量 | 31kDa |
细胞定位 | 细胞膜 |
性 状 | Liquid |
浓 度 | 批次间有差异 |
免 疫 原 | KLH conjugated Synthetic peptide corresponding to Mouse IL2RA |
亚 型 | IgG |
纯化方法 | Affinity purification |
Uniprot ID | |
缓 冲 液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
保存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
IL-2Rα(Activated T cells IL-2Rα Chain 55), also kown as membrane interleukin-2 receptor (mIL-2R) or CD25, is a protein encoded by IL2RA gene in Human. This protein is 55 kDa which is the high affinity composition of IL-2R. Few IL-2α chains will express in inactive T cells, while the expression will remarkably increase followed by IL-2 accumµLation, when T cell surface receptor (TCR) is active. IL-2αchains will become soluble interleukin-2 receptor (sIL-2R) when they are detached from cell membrane into serum, and the molecµLar weight of sIL-2R is 45 kDa. The concentration of sIL-2R in serum can be used for a mark to measure T cells activation and IL-2Rα chains expression.
