规格：50µL/100µL
货号：PN0120
价格：1350元/50µL，2200元/100 µL
全称 | Rabbit Anti-IL-10 antibody |
别名 | Interleukin-10 precursor; Cytokine synthesis inhibitory factor; CSIF; Cytokine Synthesis Inhibitory Factor; IL 10; IL10A; Interleukin 10; Interleukin10; MGC126450; MGC126451; TGIF; IL10_HUMAN. |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human, Mouse (predicted: Rat, Rabbit, Pig, Sheep, Chicken, GuineaPig) |
产品应用 | WB=1:500-2000IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500
|
理论分子量 | 18kDa |
细胞定位 | 分泌型 |
性 状 | Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human IL-10 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
Uniprot ID | |
缓 冲 液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
保存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregµLation and inflammation. It down-regµLates the expression of Th1 cytokines, MHC class II Ags, and costimµLatory molecµLes on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regµLation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregµLator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
