背景

VEGF, a homodimeric glycoprotein of relative molecµLar mass 45,000, is the only mitogen that specifically acts on endothelial cells. It may be a major regµLator of tumor angiogenesis in vivo. VascµLar endothelial growth factor is a mitogen primarily for vascµLar endothelial cells. It is, however, structurally related to platelet-derived growth factor. VEGF shares homology with the PDGF A chain and B chain, including conservation of all 8 cysteines found in PDGFA and PDGFB. VEGF gene contains 8 exons. VascµLar endothelial growth factor(VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. VEGF regµLates haematopoietic stem cell survival by an internal autocrine loop mechanism. VascµLar endothelial growth factor(VEGF) stimµLates neurogenesis in vitro and in vivo.