规格：50µL/100µL
货号：PN0217
价格：1350元/50µL；2200元/100 µL
全称 | 8-OHdG (DNA/RNA Damage) |
别名 | 8-hydroxy-2'-deoxyguanosine; 2'-Deoxy-8-oxoguanosine; 7, 8-Dihydro-8-oxo-2'-deoxyguanosine; 8-Oxo-7, 8-dihydro-2'-deoxyguanosine; 8-Oxo-7, 8-dihydrodeoxyguanosine; 2'-Deoxy-8-oxo-D-guanosine; 8-Oxo-7, 8-dihydro-2μ-deoxyguanosine, 8-Oxo-dG; 2'-Deoxy-8-hydroxyguanosine; |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Rat, Species independent |
产品应用 | IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
理论/实际分子量 | 0.283 kDa |
细胞定位 | 细胞质 |
性 状 | Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated 8-OHdG |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
缓 冲 液 | Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
保存条件 | Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecµLes that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease.
