规格：PN0070-50 µL/100 µL
货号：PN0070-50 µL/100 µL
价格：1350元/50 µL、2000元/100 µL
抗体来源 | Rabbit |
克隆类型 | Monoclonal |
交叉反应 | Human,Mouse |
产品应用 | WB 1:1000-1:2000 IHC 1:100-1:200 ICC/IF 1:50-1:200 IHF 1:50-1:200 FC 1:20-1:100 |
理论分子量 | 26kDa |
细胞定位 | 细胞质 |
性 状 | Liquid |
浓 度 | |
免 疫 原 | A synthesized peptide derived from human Bcl-2 |
亚 型 | IgG |
纯化方法 | Affinity-chromatography |
Uniprot ID | |
缓 冲 液 | pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
保存条件 | Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells . RegµLates cell death by controlling the mitochondrial membrane permeability . Appears to function in a feedback loop system with caspases . Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function . May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.
