规格：50µL/100µL
货号：PN0211
价格：1350元/50 µL ,2200元/100 µL
全称 | Alkaline phosphatase, tissue-nonspecific isozyme |
别名 | ALPL, AP-TNAP, APTNAP, HOPS, TNAP,TNSALP, Alkaline phosphatase liver/bone/kidney, TNALP |
抗体来源 | Rabbit |
克隆类型 | Monoclonal |
交叉反应 | Human, Mouse, Rat |
产品应用 | WB1:5000 - 1:30000 IHC-P1:200 - 1:2000 ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
理论分子量 | 57kDa |
细胞定位 | 细胞膜，GPI锚蛋白，脂质锚。 |
性 状 | Liquid |
浓 度 | 以具体批次为准 |
免 疫 原 | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Alkaline Phosphatase (ALPL) |
亚 型 | IgG |
纯化方法 | Affinity purification |
Uniprot ID | |
缓 冲 液 | pH: 7.2，Preservative: 0.01% Sodium azide，Constituents: 59% PBS, 0.05% BSA, 40% Glycerol (glycerin, glycerine) |
保存条件 | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particµLar tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing resµLts in mµLtiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects.
