规格：50µL/100µL
货号：PN0212
价格：1350元/50 µL ,2200元/100 µL
全称 | Tumor necrosis factor receptor superfamily member 11B |
别名 | Osteoclastogenesis inhibitory factor, Tnfrsf11b, Ocif, Opg, PDB5, TR1, TNFRSF11B, OCIF, OPG, PDB5 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Mouse, Rat |
产品应用 | IHC/IF 1:500-1:1000 |
理论分子量 | 46kDa |
细胞定位 | .分泌型 |
性 状 | Liquid |
浓 度 | 以具体批次为准 |
免 疫 原 | Recombinant protein corresponding to Human Osteoprotegerin |
亚 型 | IgG |
纯化方法 | Affinity purification |
Uniprot ID | |
缓 冲 液 | pH: 7.2，Preservative: 0.01% Sodium azide，Constituents: 59% PBS, 0.05% BSA, 40% Glycerol (glycerin, glycerine) |
保存条件 | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
