规格：50µL/100µL
货号：PN0214
价格：1350元/50 µL ,2200元/100 µL
全称 | Runt-related transcription factor 2 |
别名 | AML3, CBF alpha 1, CBFA1, CCD, CCD1, Oncogene AML 3, OSF 2, OSF2, PEA2 alpha A, PEA2aA, PEBP2 alpha A, PEBP2A, PEBP2A1, PEBP2A2, PEBP2aA, PEBP2aA1, RUNX2 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Mouse, Rat |
产品应用 | IHC/ IF: 1: 400-1: 800 |
理论分子量 | 57 kDa |
细胞定位 | 细胞核 |
性 状 | Liquid |
浓 度 | 具体批次为准 |
免 疫 原 | KLH conjugated Synthetic peptide corresponding to Human RUNX2 |
亚 型 | IgG |
纯化方法 | Affinity purification |
Uniprot ID | Q13950 |
缓 冲 液 | pH: 7.2，Preservative: 0.01% Sodium azide，Constituents: 59% PBS, 0.05% BSA, 40% Glycerol (glycerin, glycerine) |
保存条件 | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis.Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification.CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters.In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).Inhibits KAT6B-dependent transcriptional activation.
