规格：50µL/100µL
货号：PN00791
价格：1350元/50µL；2200元/100 µL
全称 | CD274 molecµLe Human, Mouse, Pig, Rat(predicted: Human, Mouse, Rat) |
别名 | B7 H, B7 H1, B7 homolog 1, B7H1, CD274, CD274 molecµLe, PD L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, PD-L1, PD-L1/CD274, Programmed death ligan |
抗体来源/类型 | Mouse Polyclonal |
交叉反应 | Human, Mouse, Pig, Rat(predicted: Human, Mouse, Rat) |
产品应用 | WB : 1:2000-1:10000 IHC : 1:5000-1:20000 IF : 1:50-1:500 FC : 0.20 ug per 10^6 cells in a 100 µl suspension |
理论分子量 | 33kDa |
细胞定位 | 细胞膜 |
性 状 | Liquid |
浓 度 | 2000ug/ml |
免 疫 原 | PD-L1/CD274 fusion protein Ag12443 |
亚 型 | IgG |
纯化方法 | Protein A purification |
Uniprot ID | |
缓 冲 液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
保存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20℃storage. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
PD-L1, also known as CD274 or B7H1, stands for programmed cell death ligand 1. It is a type I transmembrane protein that is thought to repress immune responses by binding to its receptor (PD1), thus inhibiting T-cell activation, proliferation, and cytokine production. It contains V-like and C-like immunoglobµLin domains. PD-L1 expression is regµLated by various cytokines, such as TNF-α or LPS (ISSN: 1848-7718). Increased expression of this protein in certain types of cancers, e.g., renal cell carcinoma or colon cancer, correlates with poor prognosis.
