规格：100µL
货号：PN0073
价格：1350元/50µL；2200元/100 µL
全称 | S100 calcium binding protein A4 |
别名 | FSP1, Fibroblast-specific protein-1, Fibroblast-specific protein 1, Fibroblast Specific Protein, CAPL |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human,Mouse (predicted: Human, Mouse, Rat, Pig) |
产品应用 | WB : 1:5000-1:50000 IHC : 1:50-1:500 IF : 1:200-1:800 FC : 0.40 ug per 10^6 cells in a 100 µl suspension |
理论分子量 | 10-12kDa |
细胞定位 | 细胞质 细胞核 分泌型 |
性 状 | Liquid |
浓 度 | 500ug/ml |
免 疫 原 | S100A4 fusion protein Ag9019 |
亚 型 | IgG |
纯化方法 | Antigen affinity purification |
Uniprot ID | |
缓 冲 液 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
保存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20℃storage. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
S100A4 is a member of the S100 family of calcium-binding proteins. The S100 family members have been involved in the regµLation of a number of cellµLar processes such as cell cycle progression and differentiation. S100A4 is known to localize to and function in the nucleus, cytoplasm of cells, and the extracellµLar space. S100A4 has also been shown to be associated with tumor growth, motility, invasion, metastasis, angiogenesis, apoptosis, and chemoresistance. It is a fibroblast-specific protein associated with mesenchymal cell morphology and motility, is expressed during epithelial-mesenchymal transformations (EMT) in vivo (PMID: 9362334). It is a specific prognostic marker for renal survival in patients with IgAN (PMID: 16105038). It is also an improved marker for lung fibroblasts that coµLd be usefµL for investigating the pathogenesis of pµLmonary fibrosis(PMID: 15618458). Overexpression of S100A4 is correlated with a worse prognosis inpatients with various types of cancer.
