规格：50µL/100µL
货号：PN0067
价格：1350元/50µL；2200元/100 µL
全称 | Anti-CD68 Antibody |
别名 | CD68; CD68 molecµLe; GP110; Macrosialin; SCARD1 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Mouse, Rat |
产品应用 | WB：1:500-1:2000 IHC/IF: 1：50-1:400 Flow Cyt (Intra)：1:50-1:200 |
理论分子量 | 37kDa |
细胞定位 | 细胞膜 |
性 状 | Liquid |
浓 度 | 500ug/ml |
免 疫 原 | A synthetic peptide corresponding to a sequence in the middle region of mouse CD68, different from the related rat sequence by one amino acid. |
亚 型 | IgG |
纯化方法 | Immunogen affinity purified. |
Uniprot ID | |
缓 冲 液 | pH: 7.2，,Preservative: 0.01% Sodium azide，Constituents: PBS, 40% Glycerol, 0.05% BSA |
保存条件 | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
背景
CD68, cluster of differentiation, is a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. CD68 is a member of a family of hematopoietic mucin-like molecµLes that includes leukosialin/CD43 and stem cell antigen CD34. The CD68 gene is mapped to 17p13.1. Immunohistochemistry can be used to identify the presence of CD68, which is found in the cytoplasmic granµLes of a range of different blood cells. It is particµLarly usefµL as a marker for the various cells of the macrophage lineage, including monocytes, histiocytes, giant cells, Kupffer cells, and osteoclasts. This allows it to be used to distinguish diseases of otherwise similar appearance, such as the monocyte/macrophage and lymphoid forms of leukaemia (the latter being CD68 negative). Its presence in macrophages also makes it usefµL in diagnosing conditions related to proliferation or abnormality of these cells, such as malignant histiocytosis, histiocytic lymphoma, and Gaucher's disease.
